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Heart & Vascular

Total Cholesterol

Sum of all cholesterol fractions within the lipid profile.

What is Total Cholesterol?

Total cholesterol provides a broad view but is less specific than LDL, HDL, and triglycerides. It is most useful when interpreted within the full lipid profile, including ratios and optionally ApoB. Trends help track changes over time.

Why is Total Cholesterol relevant?

Total cholesterol was historically the first cholesterol screening used and is therefore often the number people remember from a GP visit. But it is a sum: a 'high' total cholesterol driven by high HDL is very different from a 'high' total driven by high LDL. For risk assessment it is outdated as a standalone marker — it gains meaning only within the wider lipid context.

How to read Total Cholesterol in context

Always interpret total cholesterol alongside LDL, HDL, triglycerides, and — when available — ApoB and Lp(a). The total/HDL ratio is more practical than total cholesterol alone. Change over time says more than a single value: a downward trend at stable HDL and triglycerides usually indicates LDL reduction.

Total Cholesterol is one of 100+ biomarkers in the Optimize panel. Book a blood draw at any of 238+ partner labs in the Netherlands, or upload your existing results in the app.

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